{"id":2161,"date":"2026-08-07T16:55:25","date_gmt":"2026-08-07T16:55:25","guid":{"rendered":"https:\/\/kankerkneusje.nl\/?page_id=2161"},"modified":"2026-08-09T19:24:49","modified_gmt":"2026-08-09T19:24:49","slug":"waldenstrom","status":"publish","type":"page","link":"https:\/\/kankerkneusje.nl\/en\/waldenstrom\/","title":{"rendered":"Ziekte van Waldenstr\u00f6m"},"content":{"rendered":"<div data-elementor-type=\"wp-post\" data-elementor-id=\"2161\" class=\"elementor elementor-2161\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-77ccb31 elementor-section-height-min-height elementor-section-items-top elementor-section-boxed elementor-section-height-default\" data-id=\"77ccb31\" data-element_type=\"section\" data-e-type=\"section\" 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d=\"M15.6,13.2c0-0.1,4.3,0,6.7,0.5c2.4,0.5,5,1.9,5,2c0,0.1-2.7-0.8-5.1-1.4\tC19.9,13.7,15.7,13.3,15.6,13.2z\"\/>\n<\/svg>\t\t<\/div>\n\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-c6408c8 envato-kit-62-home\" data-id=\"c6408c8\" data-element_type=\"column\" data-e-type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-15c70903 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"15c70903\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-3f02fa83\" data-id=\"3f02fa83\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-2dc0652 elementor-widget elementor-widget-heading\" data-id=\"2dc0652\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Waldenstr\u00f6m's Disease: What Is It?<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4c67fe6 elementor-widget elementor-widget-text-editor\" data-id=\"4c67fe6\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Waldenstr\u00f6m's disease, also known as Waldenstr\u00f6m's macroglobulinemia or lymphoplasmacytic lymphoma, is a rare form of blood cancer. In this disease, the body produces too many abnormal white blood cells that closely resemble plasma cells. These cells mainly settle in the bone marrow, but can also spread to the lymph nodes, liver, and spleen.<\/p><p>What makes Waldenstr\u00f6m's disease distinctive is that the abnormal cells produce large amounts of a protein called IgM, also known as M-protein or macroglobulin. Normally, this protein is only present in small amounts as part of the immune system. In Waldenstr\u00f6m's disease, this balance is disrupted, leading to a range of physical symptoms.<\/p><p>The disease belongs to the group of non-Hodgkin lymphomas and is classified as an indolent, or low-grade, lymphoma. This means it usually behaves non-aggressively and tends to develop slowly.<\/p><p>How Common Is It?<\/p><p>Waldenstr\u00f6m macroglobulinemia is a rare disease. Each year, several hundred people in the Netherlands are diagnosed with it. It occurs more often in men than in women and is usually diagnosed later in life, with the average age at diagnosis ranging from 60 to 70 years. The exact cause of the disease remains unknown.<\/p><p>Symptoms<\/p><p>Not everyone with Waldenstr\u00f6m's disease experiences symptoms. In some cases, the disease is discovered by chance through blood tests, before any symptoms appear. When symptoms do occur, they often resemble those of other non-Hodgkin lymphomas:<\/p><p>Common general symptoms include weight loss, reduced appetite, fever, and night sweats. Lymph nodes may become swollen, and the spleen or liver may enlarge.<\/p><p>Because the production of healthy blood cells is disrupted, symptoms such as fatigue from anemia, an increased tendency to bleed, and a higher susceptibility to infections are also common.<\/p><p>A specific feature of Waldenstr\u00f6m's disease is hyperviscosity: the high level of abnormal IgM protein in the blood makes it thicker than normal. This can cause blurred vision, headaches, dizziness, shortness of breath, and extra strain on the heart.<\/p><p>In about one in five people, peripheral neuropathy also develops, damage to the peripheral nerves. This can cause tingling, numbness, a \"pins and needles\" sensation, or muscle weakness.<\/p><p>Diagnosis<\/p><p>Diagnosis is usually made through blood tests, which reveal an elevated IgM level. Additional testing may include a bone marrow biopsy, ultrasound, a CT scan, or a PET-CT scan, depending on the individual situation.<\/p><p>Treatment and Outlook<\/p><p>Waldenstr\u00f6m's disease cannot currently be cured, but it can be treated effectively. Because the disease usually grows slowly, treatment isn't always started right away. Doctors often choose a watch-and-wait approach as long as there are few or no symptoms.<\/p><p>If symptoms worsen, several treatment options are available, including chemo-immunotherapy, targeted therapy, and, in some cases, stem cell transplantation. In cases of acute hyperviscosity, plasmapheresis may be needed, a dialysis-like procedure that filters the excess protein out of the blood.<\/p><p>Life expectancy varies significantly from person to person and depends on factors such as age, blood values, and disease progression. On average, life expectancy after diagnosis is around 7 to 10 years, but people without symptoms can live with the disease for decades.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"<p>Ziekte van Waldenstr\u00f6m: wat is het? De ziekte van Waldenstr\u00f6m, ook wel macroglobulinemie van Waldenstr\u00f6m of lymfoplasmacytair lymfoom genoemd, is een zeldzame vorm van bloedkanker. Bij deze ziekte maakt het lichaam te veel afwijkende witte bloedcellen aan die sterk lijken op plasmacellen. Deze cellen nestelen zich vooral in het beenmerg, maar kunnen ook in de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"full-width-container","site-content-style":"unboxed","site-sidebar-style":"unboxed","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"disabled","ast-breadcrumbs-content":"","ast-featured-img":"disabled","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"slim_seo":{"title":"Ziekte van Waldenstr\u00f6m","description":"De ziekte van Waldenstr\u00f6m is een zeldzame vorm van bloedkanker. Lees over oorzaken, symptomen, diagnose en behandelmogelijkheden."},"footnotes":""},"class_list":["post-2161","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/kankerkneusje.nl\/en\/wp-json\/wp\/v2\/pages\/2161","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kankerkneusje.nl\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/kankerkneusje.nl\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/kankerkneusje.nl\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/kankerkneusje.nl\/en\/wp-json\/wp\/v2\/comments?post=2161"}],"version-history":[{"count":8,"href":"https:\/\/kankerkneusje.nl\/en\/wp-json\/wp\/v2\/pages\/2161\/revisions"}],"predecessor-version":[{"id":2246,"href":"https:\/\/kankerkneusje.nl\/en\/wp-json\/wp\/v2\/pages\/2161\/revisions\/2246"}],"wp:attachment":[{"href":"https:\/\/kankerkneusje.nl\/en\/wp-json\/wp\/v2\/media?parent=2161"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}